Sclerotherapy is the treatment of choice for small yet unsightly clusters of red, blue, or purple spider veins that most commonly appear on the thighs, legs, calves, and ankles. This simple procedure involves injecting the affected veins with a solution which causes them to immediately shrink, and then fade away over a period of weeks.  In many cases, patients require at least two treatment sessions to significantly improve the appearance of their leg veins. Sclerotherapy is known as the “gold standard” for spider vein treatment and is preferred over laser for eliminating medium and large leg spider veins.